A priori global identifiability is a structural property of biological and physiological models. It is considered a prerequisite for well-posed estimation, since it concerns the possibility of recovering uniquely the unknown model parameters from measured input-output data, under ideal conditions (noise-free observations and error-free model structure). Of… (More)
A prerequisite for well-posedness of parameter estimation of biological and physiological systems is a priori global identifiability, a property which concerns uniqueness of the solution for the unknown model parameters. Assessing a priori global identifiability is particularly difficult for nonlinear dynamic models. Various approaches have been proposed in… (More)
A priori global identifiability is a fundamental prerequisite for model identification. It concerns uniqueness of the parametric structure of a dynamic model describing given input and output functions measured during an experiment. Assessing a priori global identifiability is particularly difficult for nonlinear dynamic models. Various approaches have been… (More)
DAISY (Differential Algebra for Identifiability of SYstems) is a recently developed computer algebra software tool which can be used to automatically check global identifiability of (linear and) nonlinear dynamic models described by differential equations involving polynomial or rational functions. Global identifiability is a fundamental prerequisite for… (More)
MOTIVATION Modeling of dynamical systems using ordinary differential equations is a popular approach in the field of Systems Biology. The amount of experimental data that are used to build and calibrate these models is often limited. In this setting, the model parameters may not be uniquely determinable. Structural or a priori identifiability is a property… (More)
The relevance of model identifiability in system biology is well known. The aim of this paper is to discuss and possibly clarify the role and differences of two different methodologies of testing identifiabil-ity of models described by differential equations. One is called structural identifiability and does not require to use data collected in the… (More)
Approvazione verbale riunione precedente Il Direttore porta all'approvazione del Collegio il verbale della seduta del Collegio del 25/01/2011. Il Collegio approva all'unanimità.