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Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1‐ and Rad53‐dependent checkpoint in budding yeast
Progression through S phase of UV‐treated NER‐deficient mec1 and rad53 mutants correlates with late origin firing, suggesting that unregulated DNA replication in the presence of irreparable UV‐induced lesions might result from a failure to prevent initiation at late origins.