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Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target
Release of the malaria merozoite from its host erythrocyte (egress) and invasion of a fresh cell are crucial steps in the life cycle of the malaria pathogen. Subtilisin-like protease 1 (SUB1) is aExpand
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Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Plasmodium falciparum subtilisin-like protease 1 (PfSUB1) is a serine protease that plays key roles in the egress of the parasite from red blood cells and in preparing the released merozoites for theExpand
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Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1*
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigationExpand
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Rational design of the first difluorostatone-based PfSUB1 inhibitors.
The etiological agent of the most dangerous form of malaria, Plasmodium falciparum, has developed resistance or reduced sensitivity to the majority of the drugs available to treat this deadlyExpand
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Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors
Currently available drugs to treat malaria are often ineffective due to the acquisition of drug resistance. In this context, drugs with innovative modes of action and no liability to cross-resistanceExpand
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Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading toExpand
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