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Enantioselective Synthesis of Indole Alkaloids from Chiral Lactams
This account reports on the use of (R)- or (S)-phenylglycinol- and (S)-tryptophanol-derived oxazolopiperidone lactams as building blocks for the enantioselective synthesis of structurally diverse
Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis.
The main biological effects described for indoloquinolizidines include analgesic, anti-inflammatory, antihypertensive, and antiarrhythmic activities, as well as inhibition of multiple ion channels, affinity for opioid receptors, and activity against Leishmania.
Stereocontrolled Annulations of Indolo[2,3-a]quinolizidine-Derived Lactams with a Silylated Nazarov Reagent: Access to Allo and Epiallo Yohimbine-Type Derivatives.
The facial selectivity of double Michael addition reactions of the silylated Nazarov reagent 4 to unsaturated indolo[2,3-a]quinolizidine lactams 3 has been studied and the synthetic usefulness of the pentacyclic Nazarov-derived adducts is demonstrated by their conversion into alliallo yohimbine-type targets.
Enantiopure Indolo[2,3-a]quinolizidines: Synthesis and Evaluation as NMDA Receptor Antagonists
This compound represents a hit compound for the development of novel NMDA receptor antagonists with potential applications in neurodegenerative disorders associated with overactivation of NMDA receptors.
Diseño, síntesis y evaluación biológica de nuevos derivados de quinoxalina y 1,4-di-n-óxido de quinoxalina con aplicación en diferentes áreas terapéuticas
The results obtained show that the anticancer activity of the tested compounds is due to the a,â-unsaturated ketone system and that the presence of the N-oxide groups is not essential for this biological activity.