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Canonical Wnt signaling has been implicated in the regulation of multiple myeloma (MM) growth. Here, we investigated whether the targeting of this pathway with a novel pharmacological inhibitor ICG-001 would result in an anti-tumor effect and improvement of chemosensitivity in MM. As expected, ICG-001 specifically down-regulated β-catenin/TCF-mediated(More)
The state of serotoninergic system in thyrotoxic and euthyroid gland were compared. It was shown that in patients with hyperthyroidism (diffuse toxic goiter) serotonin and 5-hydroxytryptophan content, velocity and the latter uptake were augmented. The authors stress the role of the delay in serotonin oxidative deamination as one of the reasons for increased(More)
In the blood of patients (104) with diabetes mellitus of various severity some energy metabolic indices (lactate, pyruvate, nonesterified fatty acids, and in some patients also glycogen and glycogenolytic activity of the blood), tissue oxygen tension and immunoreactive insulin were studied simultaneously. The glycogen content, a and b phosphorylase activity(More)
OBJECTIVE Endothelial nitric oxide synthase (eNOS) is an important regulator of vascular function and its expression is regulated at post-transcriptional levels through a yet unknown mechanism. The purpose of this study is to elucidate the post-transcriptional factors regulating eNOS expression and function in endothelium. APPROACHES AND RESULTS To(More)
Multiple myeloma (MM), a blood cancer characterized by the uncontrolled proliferation of plasma cells, remains incurable by current therapy. Notch signaling has been implicated in the growth and chemoresistance of various cancer types including MM, and therefore we hypothesized that targeting the Notch pathway could be beneficial for the treatment of this(More)
Serotonin content in the blood and its main metabolite 5-hydroxyindolacetic acid concentration in the urine were studied in 65 patients suffering from thyrotoxicosis of different severity and duration. The serotonin level was significantly lower in comparison with that of the control group (36 healthy subjects) while the daily excretion of(More)