Maria Nicolais

Learn More
OBJECTIVES Tyrosine kinase inhibitor (TKI)-treated acute myeloid leukemia (AML) patients commonly show rapid and significant peripheral blood blast cell reduction, however a marginal decrease in bone marrow blasts. This suggests a protective environment and highlights the demand for a better understanding of stromal:leukemia cell communication. As a(More)
Activation of the transcription factor STAT5 is essential for the pathogenesis of acute myelogenous leukemia (AML) containing the FLT3 internal tandem duplication (ITD) mutation. FLT3 ITD is a constitutively active tyrosine kinase that drives the activation of STAT5, leading to the growth and survival of AML cells. Although there has been some success in(More)
Inappropriate expression or activation of transcription factors can drive patterns of gene expression, leading to the malignant behavior of breast cancer cells. We have found that the transcriptional repressor BCL6 is highly expressed in breast cancer cell lines, and its locus is amplified in about half of primary breast cancers. To understand how BCL6(More)
The effect of dietary wheat bran and dehydrated citrus fiber on carcinogenesis of the colon and small intestine was studied in male F344 rats. Weanling rats were fed semi-purified diets containing 5% fat and 15% wheat bran or citrus fiber. At 7 weeks of age, all animals, except vehicle-treated controls, received weekly sc injections of 8 mg azoxymethane(More)
  • 1