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  • Vincent Chi Hang Lui, William Wai-Chun Cheng, +9 authors Paul K. H. Tam
  • Biology, Medicine
  • Gastroenterology
  • 2008 (First Published: 1 April 2008)
  • BACKGROUND & AIMS The enteric nervous system (ENS) controls intestinal peristalsis, and defective development of this system results in hypo/aganglionosis, as seen in Hirschsprung's disease. In theContinue Reading
  • Maria-Mercedes Garcia-Barceló, Lok Yee Chow, +4 authors Mary Miu Yee Waye
  • Medicine, Biology
  • Clinical chemistry
  • 1999 (First Published: 1 December 1999)
  • A genetic polymorphism in the metabolism of the anticonvulsant drug mephenytoin in humans is a prime example of interracial and individual variability in drug metabolism. This polymorphism affectsContinue Reading
  • Frank Pui-Ling Lai, Sin-Ting Lau, +8 authors Elly Sau-wai Ngan
  • Biology, Medicine
  • Gastroenterology
  • 2017 (First Published: 1 July 2017)
  • BACKGROUND & AIMS Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations inContinue Reading
  • Jessica Aijia Liu, Frank Pui-Ling Lai, +5 authors Elly Sau-wai Ngan
  • Biology, Medicine
  • Gastroenterology
  • 2015 (First Published: 1 December 2015)
  • BACKGROUND & AIMS Hirschsprung disease is characterized by a deficit in enteric neurons, which are derived from neural crest cells (NCCs). Aberrant hedgehog signaling disrupts NCC differentiation andContinue Reading
  • Maria-Mercedes Garcia-Barceló, Stephen Kwok-Wing Tsui, Stephen SC Chim, Kwok Pui Fung, Cheuk Yu Lee, Mary Miu Yee Waye
  • Biology, Medicine
  • Genomics
  • 1998 (First Published: 1 February 1998)
  • We report here on the mapping of a cDNA encoding for human cysteine-rich heart protein (HCRHP), a counterpart of the murine cysteine-rich intestinal protein CRIP. By somatic cell hybrid analysis andContinue Reading
  • Vincent Chi Hang Lui, Thomas Yuk-yu Leon, +4 authors Paul Kwong-hang Tam
  • Biology, Medicine
  • Clinical chemistry
  • 2005 (First Published: 1 August 2005)
  • The RET gene encodes a transmembrane receptor tyrosine kinase, RET (1)(2), which is produced by enteric nervous system progenitors and functions, together with glial cell-line–derived neurotrophicContinue Reading