Maria M. Sokolova

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In this work, we map the transcriptional targets of 107 previously identified Drosophila genes whose loss caused the strongest cell-cycle phenotypes in a genome-wide RNA interference screen and mine the resulting data computationally. Besides confirming existing knowledge, the analysis revealed several regulatory systems, among which were two(More)
To identify cell cycle regulators that enable cancer cells to replicate DNA and divide in an unrestricted manner, we performed a parallel genome-wide RNAi screen in normal and cancer cell lines. In addition to many shared regulators, we found that tumor and normal cells are differentially sensitive to loss of the histone genes transcriptional regulator(More)
BACKGROUND Protective perioperative ventilation has been shown to improve outcomes and reduce the incidence of postoperative pulmonary complications. The goal of this study was to assess the effects of ventilation with low tidal volume (VT) either alone or in a combination with moderate permissive hypercapnia in major pancreatoduodenal interventions. (More)
Morpho-functional changes in scorpionfish pinealocytes have been observed during an increase in potassium sodium or magnesium content of the sea water. These changes include the increase in the height and the diameter of the nuclei of pinealocytes, the increase being followed by apocrynic secretion in the cells. It is suggested that the pineal organ of the(More)
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