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  • Mark G Lewis, Sandro Norelli, +8 authors Andrea Savarino
  • Biology, Medicine
  • Retrovirology
  • 2009 (First Publication: 16 March 2010)
  • BackgroundIn this study we successfully created a new approach to ART in SIVmac251 infected nonhuman primates. This drug regimen is entirely based on drugs affecting the pre-integration stages ofContinue Reading
  • Andrea Savarino, Mauro Pistello, +11 authors Mauro Bendinelli
  • Biology, Medicine
  • Retrovirology
  • 2007 (First Publication: 30 October 2007)
  • BackgroundTreatment of feline immunodeficiency virus (FIV) infection has been hampered by the absence of a specific combination antiretroviral treatment (ART). Integrase strand transfer inhibitorsContinue Reading
  • Stefano Sabatini, Francesca Gosetto, +8 authors Violetta Cecchetti
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2013 (First Publication: 27 June 2013)
  • Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of antimicrobial agents that are substrates. NorA is a Staphylococcus aureus efflux pump that confersContinue Reading
  • Maria Letizia Barreca, Keun Woo Lee, Alba Chimirri, Judson C. Briggs
  • Biology, Medicine
  • Biophysical journal
  • 2003 (First Publication: 1 March 2003)
  • The human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the life cycle of the virus and is an attractive target for the development of new drugs useful in acquiredContinue Reading
  • Maria Letizia Barreca, Jan Balzarini, +9 authors Maria Zappalà
  • Chemistry
  • 2002 (First Publication: 1 November 2002)
  • Starting from 1H,3H-thiazolo[3,4-a]benzimidazoles (TBZs), we performed the design, synthesis, and the structure−activity relationship studies of a series of 2,3-diaryl-1,3-thiazolidin-4-ones. SomeContinue Reading
  • Sandro Norelli, Sary El Daker, +11 authors Andrea Savarino
  • Biology, Medicine
  • Current HIV research
  • 2008 (First Publication: 1 July 2008)
  • The feline AIDS model for HIV-1 treatment failed in the 1990s, due to structural features resembling protease inhibitor (PI) resistant HIV-1 variants. Widespread drug-resistance to PIs now invokesContinue Reading