Maria-José Castro

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Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetetrahydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of(More)
INTRODUCTION A spontaneous cervical epidural hematoma is an infrequent cause of cord compression. The commonest clinical presentations are with paraparesia and tetraparesia. Transient hemiparesia is very rare and a sensory-motor syndrome is exceptional. CLINICAL CASE A 38 year old man had sudden onset of spontaneous interscapular vertebral pain with(More)
Mitochondrial disorders are multisystemic diseases with very heterogeneous clinical manifestations. A same genetic mutation can result in distinctive clinical phenotypes and, on the other hand, distinct mutations can result in the same clinical phenotype. This article review the manifestations of the diverse clinical syndromes, their relationship with the(More)
INTRODUCTION The one and a half vertical syndrome consists of paralysis of upward vertical conjugated gaze and monocular paralysis of downward gaze or vice-versa. It occurs as a consequence of a mesencephalodiencephalic lesion, either unilaterally or bilaterally, due to effects on structures such as the interstitial nucleus of Cajal, posterior commissure(More)
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