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To establish whether adrenal corticosterone secretion is episodic and whether episodes are random or periodic events, adrenal extracellular fluid was sampled in awake rats by intra-adrenal microdialysis. Experiments conducted 1 or 2 days postsurgery between 1000 and 1830 h consisted of continuous collection of dialysate at intervals of 10 min. Pulses(More)
An ultradian rhythm in adrenal secretion of corticosterone has been described in awake rats using intra-adrenal microdialysis. To determine the role of the autonomic innervation of the adrenal on the expression of the corticosterone rhythm, adrenal extracellular fluid was sampled by intra-adrenal microdialysis in intact (CTRL) and splanchnicectomized(More)
Awake rats demonstrate an ultradian rhythm in adrenal secretion of corticosterone. Splanchnic denervation in unstressed rats increases the frequency of corticosterone pulses, revealing an inhibitory function of adrenal innervation. In contrast, one day after surgical stress, adrenal denervation reduces adrenal pulsatility, suggesting a stimulatory function(More)
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