Maria Ines Gutierrez

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BACKGROUND An essential event during the replication cycle of HIV-1 is the integration of the reverse transcribed viral DNA into the host cellular genome. Our former report revealed that HIV-1 integrase (IN), the enzyme that catalyzes the integration reaction, is positively regulated by acetylation mediated by the histone acetyltransferase (HAT) p300. (More)
Various members of tripartite motif (TRIM) protein family display antiviral properties, targeting retroviruses in particular. The potential activity of TRIM19, better known as promyelocytic leukemia protein (PML) against several viruses has been well documented, yet it's role in HIV-1 infection remains elusive. One of the most important cellular partners of(More)
Post-translational modifications, such as acetylation, dynamically modulate the chemical and structural properties of proteins generating new protein-protein interfaces. HIV-1 integrase is acetylated by p300 at three specific lysines located in the carboxy terminal domain. In the attempt to understand how acetylation modifies the integration event, we have(More)
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