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OBJECTIVE To identify the temporal sequence of abnormal Doppler changes in the fetal circulation in a subset of early and severely growth-restricted fetuses. METHODS This was a prospective observational study in a tertiary care/teaching hospital. Twenty-six women who were diagnosed with growth-restricted fetuses by local standards before 32 weeks'(More)
The role of imaging in functioning endocrine tumours (FETs) is primarily to detect the tumour, that is, to verify lesion number and location. Radiological detection of carcinoid tumours is limited by typical tumour location throughout the gastrointestinal tract or appendix and is therefore dependent on the tumour being large enough to make it recognisable(More)
Autonomic regulation of blood flow through the fetal ductus venosus has been suggested, but the existence of a sphincter at the ductal entrance in human fetuses has yet to be established. In this paper two cases of apparent ductus venosus dilatation in two growth-restricted human fetuses are reported. Prolonged ultrasonographic analysis (45 min) showed(More)
OBJECTIVE To correlate the peak velocities of the aortic outflow tract of growth-retarded fetuses with fetal acid base status and oxygenation measured in utero. METHODS Thirty-one growth-retarded fetuses with abnormal umbilical pulsatility index (PI) measurements underwent fetal blood sampling. Blood pH, carbon dioxide pressure (PCO2), oxygen pressure(More)
The relationship between in utero fetal growth and fetal leptin concentrations was investigated between 19 and 41 wk in 40 normal (appropriate for gestational age, AGA) fetuses, in 25 intrauterine growth-restricted (IUGR) fetuses, and in 18 fetuses from gestational diabetic mothers (GDM), representing different intrauterine growth patterns. Umbilical venous(More)
We investigated the hemodynamics of the ductus venosus in the human fetus by means of a combined approach based on Doppler and computational techniques. The aim of our study was to assess the blood velocity changes across the ductus venosus. Color Doppler equipment was used to investigate 29 normal fetuses between 20 and 39 weeks of gestation. Velocities at(More)
OBJECTIVE To determine whether umbilical blood flow is reduced in a subset of growth-restricted (IUGR) fetuses when expressed as flow per kilogram or flow per unit of specific sonographic fetal measurements. DESIGN Prospective. SUBJECTS Thirty-seven IUGR fetuses were examined by Doppler ultrasound within 4 h of the last non-stress test prior to(More)
OBJECTIVE We have previously shown, in a cross-sectional study, that the reduction in umbilical vein blood flow in intrauterine growth-restricted fetuses is due to reduced umbilical vein velocity. The purpose of this longitudinal study in intrauterine growth-restricted fetuses was to determine whether the umbilical vein velocity reduction, which, in turn,(More)
OBJECTIVE The purpose of this study was to evaluate the changes in the distribution of the umbilical venous blood flow to the liver and to the ductus venosus in intrauterine growth-restricted human fetuses in relationship with dilation of the ductal isthmic diameter. STUDY DESIGN Umbilical venous flow, ductus venosus blood flow, and blood flow to the(More)
The partitioning of umbilical vein blood flow between fetal liver and ductus venosus may be an indicator of the fetal well-being, because the goal of the ductus venosus is to supply oxygen and nutrients to heart and brain. Both distribution and blood flow rate of the umbilical vein are functions of the local vascular impedances that, in turn, depend on the(More)