Maria Gaitatzi

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We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a(More)
Monosomal karyotype (MK) has recently been reported to identify a distinct subset of acute myeloid leukemia (AML) with adverse prognosis. We retrospectively evaluated the frequency of MK in a large cohort of 549 unselected AML cases diagnosed in our department over a period of 13 years and explored potential associations with clinicobiological features and(More)
In a cohort of 130 unselected chronic lymphocytic leukemia (CLL) patients, 73 cases had normal karyotypes, 57 cases had abnormal karyotypes, and 22/57 cases carried more than one abnormality. Trisomy 12 (+12) was the most common abnormality (26/130 cases; 20%), and 17/26 cases had isolated +12. Del(13q)/t13q/-13 was detected in 19/130 cases (14.6%), and(More)
Several extracellular proteins have been reported to be phosphorylated. Previous studies of our laboratory indicated that laminin-1 can be phosphorylated by protein kinase A (PKA). Moreover, it has been reported that protein kinase C (PKC), although known to be intracellular, can phosphorylate extracellular proteins in the case of cellular damage and/or(More)
The most frequent cause of treatment failure after allogeneic hematopoietic cell transplantation (allo-HCT) for leukemia is relapse of the underlying host leukemia. However, occasionally, cytogenetic analysis, alone or in combination with molecular analysis, has indicated that the new leukemia originated in donor cells (DC). Leukemic transformation of DC(More)
Pathological changes in the urine sodium dodecyl sulphate gel electrophoresis (SDS PAGE) patterns often precede the occurrence of any sign of renal involvement in diabetes. However, data concerning the most frequent SDS PAGE pattern of the urine in early stages of type I diabetes mellitus are controversial. In the present study an SDS PAGE technique has(More)
Band q22 of chromosome 21 contains the RUNX1 gene (alias AML1 or CBF-alpha; CBFa), which is critical for hematopoiesis and undergoes fusion with a variety of genes in de novo and therapy-related acute myeloid leukemia (AML). Amongst them, the t(8;21)(q22;q22) involves the RUNX1 and MTG8 (Myeloid Translocation Gene on chromosome 8; also known as RUNX1T1)(More)
Pentasomy 8 as a sole anomaly in hematological disorders is rare. Only 2 such cases, one in acute monocytic leukemia and one in chronic myelomonocytic leukemia have been described in the literature to date. Here, we report the first case of a 42 year old man with erythroleukemia displaying a pentasomy 8 clone. Conventional cytogenetics of bone marrow cells(More)
Imatinib mesylate (IM) is the first tyrosine kinase inhibitor (TKI) introduced for the treatment of chronic myelogenous leukemia (CML) with remarkable high rates of complete hematologic and cytogenetic response and an acceptable safety and toxicity profile. Clonal aberrations (CAs) in Philadelphia (Ph)-chromosome negative metaphases have been reported in(More)