Maria Feilcke

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There is wide agreement on the benefits of NBS for CF in terms of lowered disease severity, decreased burden of care, and reduced costs. Risks are mainly associated with disclosure of carrier status and diagnostic uncertainty. When starting a NBS programme for CF it is important to take precautions in order to minimise avoidable risks and maximise benefits.(More)
OBJECTIVE To identify cystic fibrosis (CF) patients with a history of meconium ileus (MI) and to compare long-term outcome of these patients with CF patients without MI. PATIENTS 370 CF patients who were treated at the Munich CF centre in 2006, mean age 17.1 years (range: 0-48), were classified with regard to a history of MI. METHODS Retrospective chart(More)
BACKGROUND Patient dependent parameters to predict the long-term success of early eradication treatment of Pseudomonas aeruginosa have not yet been defined. For this purpose we assessed serum antibodies against P. aeruginosa in CF patients after early eradication treatment. METHODS Retrospective analyses of all consecutive patients with first P.(More)
Paul Ehrlich hatte bereits vor über 100 Jahren die starke Reaktion des Immunsystems auf Fremdantigene erkannt. In Tierversuchen erkannte er die zerstörerischen Wirkungen dieser Abwehr auch gegen den eigenen Organismus (Horror autotoxicus, Ehrlich und Morgenroth, 1901). Seither sind zahlreiche Autoimmunerkrankungen beschrieben worden. Teils richtet sich das(More)
BACKGROUND Induced sputum is the most commonly used method to analyze airway inflammation in cystic fibrosis (CF) patients ex vivo. Due to the complex matrix of the sample material, precise and reliable analysis of sputum constituents depends critically on preanalytical issues. OBJECTIVES Here we compared the commonly used method for sputum processing by(More)
BACKGROUND Aim of this study was to verify a systematic and practical categorization system that allows dynamic classification of pediatric DPLD irrespective of completeness of patient data. METHODS The study was based on 2322 children submitted to the kids-lung-register between 1997 and 2012. Of these children 791 were assigned to 12 DPLD categories,(More)
OBJECTIVE To retrospectively identify CF patients with methicillin resistant Staphylococcus aureus (MRSA) and to assess the long-term success of an eradication scheme introduced in 2002 for all newly colonized patients. PATIENTS All microbiological results from all 505 CF patients followed between 2002 and 2012 were analyzed focusing on the detection of(More)
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