Maria F. Chacon‐Heszele

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Cilia, organelles that function as cellular antennae, are central to the pathogenesis of "ciliopathies", including various forms of polycystic kidney disease (PKD). To date, however, the molecular mechanisms controlling ciliogenesis and ciliary function remain incompletely understood. A recently proposed model of cell-cell communication, called "urocrine(More)
The vertebrate planar cell polarity (PCP) pathway consists of conserved PCP and ciliary genes. During development, the PCP pathway regulates convergent extension (CE) and uniform orientation of sensory hair cells in the cochlea. It is not clear how these diverse morphogenetic processes are regulated by a common set of PCP genes. Here, we show that cellular(More)
Planar cell polarity (PCP) refers to coordinated polarization of cells in the plane of a cell sheet. In Drosophila, the stereotypical arrangement of the eight photoreceptor cells in each of the ommatidia of the fly compound eye and the uniform orientation of the hairs in all the wing cells are two representative forms of PCP. Using these powerful Drosophila(More)
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