Maria Elisabete V Costa

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BACKGROUND The increasing availability of reference libraries of DNA barcodes (RLDB) offers the opportunity to the screen the level of consistency in DNA barcode data among libraries, in order to detect possible disagreements generated from taxonomic uncertainty or operational shortcomings. We propose a ranking system to attribute a confidence level to(More)
Hydroxyapatite (Hap) is a calcium phosphate with a chemical formula that closely resembles that of the mineral constituents found in hard tissues, thereby explaining its natural biocompatibility and wide biomedical use. Nanostructured Hap materials appear to present a good performance in bone tissue applications because of their ability to mimic the(More)
Hydroxyapatite (HAP) particles with different morphologies were precipitated from homogeneous calcium/citrate/phosphate solutions at physiological temperature. Small variations of the starting solution pH in the range 7.4<pH<8.5 made it possible to switch the precipitated particle morphology from a micrometric bundlelike to a nanometric needlelike shape.(More)
In our previous work we described the preparation and characterization of spray dried hydroxyapatite micro granules loaded with 5-fluorouracil (5-FU). These loaded particles are used as a model drug delivery system (DDS). In this study we examined the in vitro response of two cell lines derived from different tissues to 5-FU loaded granules (LG). Both cell(More)
Nanosized hydroxyapatite (HA) is a promising material in clinical applications targeting the bone tissue. NanoHA is able to modulate bone cellular events, which accounts for its potential utility, but also raises safety concerns regarding the maintenance of the bone homeostasis. This work analyses the effects of HA nanoparticles (HAnp) on osteoclastic(More)
The relationship between charge transport, defects and ferroelectric response is established for K0.5Na0.5NbO3 (KNN) and Mn-doped KNN ceramics. At room temperature the conduction in KNN is associated with hole transport and can be suppressed by Mn doping. Because of that a less leaky ferroelectric hysteresis loop is obtained for Mn-doped KNN. At high(More)
In this study we present a three-dimensional angiogenesis assay in vitro that allows the evaluation of the influence of Poly(lactic-co-glycolic acid) based implants seeded with VEGF-A165 stimulated/activated human CD14+ monocytes on the attraction and migration of human micro vascular endothelial cells (HMVEC-L). Primary HMEC of the capillary bed were(More)
The largest piezoelectric properties, d33 = 416 pC/N and 490 pC/N, in KxNa1-xNbO3 ceramics have been reported for compositions close to polymorphic phase transition (PPT); however, they also have Curie temperatures, TC, of around 217-304 °C, considerably lower than those of undoped KNN ceramics (420 °C). High d33 along with high TC remains the ideal choice(More)
Recently it has been shown that folic acid can have an important role in bone regeneration. For this reason, combining a classic bone regeneration system as, hydroxyapatite, loaded with folic acid, may be an important issue to be developed. To address this issue, hydroxyapatite nanoparticles loaded with folic acid were designed as an effective bone(More)
A current challenge for the fabrication of functional oxide-based devices is related with the need of environmental and sustainable materials and processes. By considering both lead-free ferroelectrics of potassium sodium niobate (K0.5Na0.5NbO3, KNN) and aqueous-based electrophoretic deposition here we demonstrate that an eco-friendly aqueous solution-based(More)