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Over the last 30 years there has been considerable interest in the use of functional electrical stimulation (FES) to restore movement to the limbs of paralyzed patients. Spinal cord injury causes a rapid loss in both muscle mass and contractile force. The atrophy is especially severe when the injury involves lower motoneurons because many months after(More)
Following denervation, skeletal muscle undergoes rapid loss in both mass and contractile force, with an accompanying series of changes in structure, biochemistry and physiology. Morphologic features of the long-term denervated muscle suggest that the original fibers are lost and those seen are the results of repeated cycles of cell death and regeneration.(More)
BACKGROUND There is increasing evidence that matrix metalloproteinases (MMPs) may contribute to the pathogenesis of COPD, but their role in humans is not completely understood. We performed this study to quantify the expression of MMP-2 in a population of COPD patients at different stages of severity. METHODS We collected surgical specimens from 46(More)
RATIONALE Airway remodeling and inflammation are characteristic features of adult asthma that are still poorly investigated in childhood asthma. OBJECTIVES To examine epithelial and vascular changes as well as the inflammatory response in airways of children with asthma. METHODS We analyzed bronchial biopsies obtained from 44 children undergoing(More)
RATIONALE Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears to resolve by adolescence in nonatopic children. OBJECTIVES To investigate whether among children with multitrigger wheeze responsive to bronchodilators the airway pathology would be(More)
Skeletal muscle regeneration is a powerful, naturally occurring process of tissue reconstruction that follows myofiber damage secondary to myotoxic injury that does not normally affect the tissue circulation and scaffold. The ablated tissue, in traumatology and free muscle grafts, is frequently replaced by scars. The final outcome is poor even after in situ(More)
Following denervation, skeletal muscle undergoes rapid loss in both mass and contractile force, with an accompanying series of changes in structure, biochemistry and physiology. Morphologic features of the long-term denervated muscle suggest that the original fibers are lost and those seen are the results of repeated cycles of cell death and regeneration.(More)
Insulin-dependent diabetes mellitus is caused by autoimmune destruction of pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop diabetes similar to the human disease. Cytokines produced by islet-infiltrating mononuclear cells may be directly cytotoxic and can be involved in islet destruction coordinated by CD4+ and CD8+ cells. We(More)
In human diseases, skeletal muscle regeneration is a powerful, naturally-occurring process of tissue reconstruction that follows upon myofiber damage secondary to injury, which does not affect the tissue circulation and scaffold. On the other hand, the ablated tissue, in traumatology and free muscle grafting, is commonly seen to be replaced by scars. The(More)
Severe atrophy of skeletal muscles occurs during long-term permanent denervation (LT-PD). We studied 14 human muscle biopsies taken from patients suffering lower motoneuron denervation from 2 to 30 years. Patients were treated with Functional Electrical Stimulation (FES) for different periods of time (0.5 to 6 years). We describe new gel electrophoresis(More)
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