Maria Elena Zanin

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Over the last 30 years there has been considerable interest in the use of functional electrical stimulation (FES) to restore movement to the limbs of paralyzed patients. Spinal cord injury causes a rapid loss in both muscle mass and contractile force. The atrophy is especially severe when the injury involves lower motoneurons because many months after(More)
Following denervation, skeletal muscle undergoes rapid loss in both mass and contractile force, with an accompanying series of changes in structure, biochemistry and physiology. Morphologic features of the long-term denervated muscle suggest that the original fibers are lost and those seen are the results of repeated cycles of cell death and regeneration.(More)
Following denervation, skeletal muscle undergoes rapid loss in both mass and contractile force, with an accompanying series of changes in structure, biochemistry and physiology. Morphologic features of the long-term denervated muscle suggest that the original fibers are lost and those seen are the results of repeated cycles of cell death and regeneration.(More)
In human diseases, skeletal muscle regeneration is a powerful, naturally-occurring process of tissue reconstruction that follows upon myofiber damage secondary to injury, which does not affect the tissue circulation and scaffold. On the other hand, the ablated tissue, in traumatology and free muscle grafting, is commonly seen to be replaced by scars. The(More)
Severe atrophy of skeletal muscles occurs during long-term permanent denervation (LT-PD). We studied 14 human muscle biopsies taken from patients suffering lower motoneuron denervation from 2 to 30 years. Patients were treated with Functional Electrical Stimulation (FES) for different periods of time (0.5 to 6 years). We describe new gel electrophoresis(More)
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