Maria Dolores De Las Marinas

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This review addresses the problem of lupin sensitization in the home environment. We summarize the data currently available on allergy to lupin, which has become, in recent years, a hidden killer in our homes. Since 2006, when lupin was included in European regulations as a food whose presence must be declared, the situation may have changed. Nevertheless,(More)
In this study, we evaluated the evolution of IgG subclasses in the course of immunotherapy, and related this to the clinical evolution. We selected 226 adult patients with sensitivity to grass pollen alone, undergoing immunotherapy for 0-26 months. The following results may be highlighted: 1) IgG1 increased with immunotherapy and reached its peak at 6(More)
Extrinsic allergic alveolitis (EAA) are clinical entities of growing importance. The discovered etiological agents which can induce them, organic and inorganic substances of low molecular weight which are frequently found in the laboral environment, are every day more numerous. In the group of substances which are rarely implied in EAA etiology, we must(More)
The isotype-specific mechanisms involved in IgE synthesis are a sophisticated system about which very little is known. Several research groups have demonstrated that there is an enhancing factor (EF) in lymphocyte supernatants which is related to the regulation of the synthesis of IgE, and the influence medium-long-term immunotherapy (IT) exerts on it.(More)
In this study, we used an in vitro experimental model with peripheral mononuclear cells (PBMCs) capable of synthesizing IgE to study the possible parallelism between in vitro IgE synthesis and the findings obtained in vivo showing changes in serum IgE values during immunotherapy (IT). Blood samples were extracted from 10 healthy subjects and 39 allergic(More)
IgE synthesis is controlled not only by antigen-specific mechanism but also by other factors which selectively affect the IgE isotype. Several groups demonstrated that factors released by lymphocytes were involved in this regulation. Our previous investigations were also directed in this field. Immunotherapy improves clinical symptoms in allergic(More)
In previous studies we described isotype-specific but antigen non-restricted soluble factors produced by human lymphocytes. In subsequent studies we demonstrated changes in the production of these factors during the course of immunotherapy (IT) by testing them on lymphocytes from normal healthy controls and allergic patients. Through these studies we(More)