Maria D. Dănilă

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Diabetes mellitus (DM) is widely recognized as the most severe metabolic disease associated with increased cardiovascular morbidity and mortality. The generation of reactive oxygen species (ROS) is a major event causally linked to the development of cardiovascular complications throughout the evolution of DM. Recently, monoamine oxidases (MAOs) at the outer(More)
Monoamine oxidases (MAOs) have recently emerged as important mitochondrial sources of oxidative stress in the cardiovascular system. Generation of reactive oxygen species during the brief episodes of ischemic preconditioning (IPC) is responsible for the cardioprotection at reperfusion. The aim of this study was to assess the effects of two MAO inhibitors(More)
A substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (mKATP) in the heart is protective in conditions associated with ischemia/reperfusion injury. Several mechanisms have been postulated to be responsible for cardioprotection, including the modulation of mitochondrial respiratory(More)
ADRIAN STURZA1,2#, LAVINIA NOVEANU1,2#, OANA DUICU1,2 MARIA DANILA1,2, NORBERT JOST1,2, DANINA MUNTEAN1,2*, MIRCEA MUNTEANU3 1“Victor Babes University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2 “Victor Babes University of Medicine and Pharmacy, Center for Translational(More)
OANA M. DUICU1,2, ILEANA SCURTU1, ROXANA POPESCU3, ADRIAN STURZA1,2, DORINA CORICOVAC4, MARIA D. DANILA1,2, ANDREEA PRIVISTIRESCU1, DANINA M. MUNTEAN1,2,* 1“Victor Babes” University of Medicine and Pharmacy Timisoara, Department of Pathophysiology, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2“Victor Babes” University of Medicine and Pharmacy Timisoara,(More)
VIORICA KERTI1#, DORINA CORICOVAC2#, OANA DUICU1, MARIA DANILA1, CRISTINA DEHELEAN2, EUGENIA FAGADARCOSMA3, DANINA MUNTEAN1*, LAVINIA NOVEANU1 1 “Victor Babeo”University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 2 Eftimie Murgu Sq., 300041, Timiooara, Romania 2 “Victor Babeo” University of Medicine and Pharmacy, Faculty(More)
Diabetic cardiomyopathy has been systematically associated with compromised mitochondrial energetics and increased generation of reactive oxygen species (ROS) that underlie its progression to heart failure. Methylene blue is a redox drug with reported protective effects mainly on brain mitochondria. The purpose of the present study was to characterize the(More)
Ischaemia/reperfusion (I/R) injury of the heart represents a major health burden mainly associated with acute coronary syndromes. While timely coronary reperfusion has become the established routine therapy in patients with ST-elevation myocardial infarction, the restoration of blood flow into the previously ischaemic area is always accompanied by(More)
There is a growing body of evidence pointing to the role of purinergic signaling in the development and progression of various conditions that have inflammation as a common pathogenetic denominator. The aim of the present study was to assess the involvement of P2Y11 purinergic receptors in the regulation of vascular function in aortic segments obtained(More)
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