Maria Costa

Learn More
The Myc oncogene regulates the expression of several components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, RNA polymerase III and ribosomal DNA. Whether and how increasing the cellular protein synthesis capacity affects the multistep process leading to cancer remains to be addressed. Here we use(More)
Sulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. Notwithstanding, in different cancer cell lines, SFN may promote the accumulation of reactive oxygen species (ROS) and cause cell death e.g. by apoptosis. Osteosarcoma often becomes chemoresistant, and new molecular targets to prevent drug(More)
B-cell maturation occurs in several steps and requires constant stimulus for its continuing development. From the emergence of the pre-B-cell receptor, signal transduction stimulates and supports B-cell development. Current viewpoints indicate that both positive selection pressure for autoantigens and tonic signaling constitutively stimulate B-cell(More)
In both lay and academic circles, it is not common to find the term postcolonial associated with Latin America, and perhaps even less so with Brazil. This probably has to do with the dynamics of this idea, a relatively recent construct that was born overseas and has circulated mostly in Anglophone scholarly environments other than Latin America. But this(More)
In the last few years there has been an increase in development of digital games to be used on mobile devices for children as young as babies. Although prestigious organizations such as the American Academy of Pediatrics recommend that children shouldn't use screens until they are at least 2 years old, the first studies show that a relevant number of(More)
  • 1