Maria Copeland

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PURPOSE The impact of the presence of a germ-line BRCA1 mutation on gene expression in normal breast fibroblasts after radiation-induced DNA damage has been investigated. EXPERIMENTAL DESIGN High-density cDNA microarray technology was used to identify differential responses to DNA damage in fibroblasts from nine heterozygous BRCA1 mutation carriers(More)
Understanding ontology evolution is becoming an active topic of interest to ontology engineers, e.g., we have large collaborative developed ontolo-gies but, unlike software engineering, comparatively little is understood about the dynamics of historical changes, especially at a fine level of granularity. Only recently has there been a systematic analysis of(More)
The Software Ontology Project (SWO) is a community effort to build an ontology that models software used in the generation and analysis of data for curation and preservation purposes in areas such as biomedicine. In community driven efforts, requirements are elicited from the members of these communities to help ensure the ontology is fit for purpose. This(More)
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