Maria Cochran

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Fundamental questions arising from study of the multiple sclerosis lesion are: (1) why the myelin-forming oligodendrocyte is adversely affected; and (2) what factors might induce the proliferation and differentiation of replacement oligodendrocytes. This paper discusses factors that influence the number and differentiative capacity of myelin-forming cells(More)
We have investigated mouse and rat ganglionic Schwann cells as possible sources of neurite outgrowth-promoting factors by co-culturing Schwann cells with nerve growth factor (NGF)-responsive PC12 pheochromocytoma cells primed by pretreatment with NGF. NGF-primed PC12 cells are capable of neurite regeneration when provided with an appropriate neurite(More)
Schwann cells derived from mouse or rat dorsal root ganglia (DRG) were co-cultured with either DRG neurons or nerve growth factor (NGF)-responsive PC12 pheochromocytoma cells for up to 7 weeks. When Schwann cells were grown in the presence of DRG neurites, they displayed normal ensheathing behavior and produced basal laminae and small diameter collagen(More)
ii Acknowledgements As Goose says in Top Gun, the list of people who I need to thank is " long but distinguished. " I must first thank Dr. Shulin Li for being such a wonderfully supportive mentor. Throughout my graduate program, his guidance and advice were always there to motivate and teach me. He has made my tenure in this program a truly excellent(More)
Cultures of Schwann cells and neurons from dorsal root ganglia of normal (C57bl/6J +/+) and dystrophic (C57bl/6J dy2j/dy2j) mice were labeled with wheat germ agglutinin (WGA) and Ricinus communis agglutinin (RCA-I) conjugated to ferritin. Statistical methods were used to compare the regional densities and distribution characteristics of lectin binding in(More)
Organotypic dorsal root ganglion (DRG) cultures were established from all the embryos of two trembler (Tr/+) female mice mated to normal (+/+) males to determine if the trembler mutation would be expressed in nerve tissue culture. Dorsal root ganglia from normal mice maintained in our culture system exhibit substantial myelination after 6 weeks of growth.(More)
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