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The effects of 17 h food deprivation and stimulation by five concentrations (0.05-0.8 M) of sucrose solutions on the licking behavior of rats were investigated. Food deprivation increased the intake of the three lowest concentrations (0.05, 0.1, and 0.2 M) but had no effect on the volume ingested of the two highest concentrations (0.4 and 0.8 M). Food(More)
Behavioral and electrophysiological features of sleep and wakefulness were studied in chronically implanted adult parakeets, Aratinga canicularis. Four states of vigilance were observed: (1) Wakefulness. It is divided into active and passive. During this state there are generalized motor manifestations which are more frequent and intense in active(More)
Individuals of Gopherus flavomarginatus, previously adapted to experimental conditions were chronically implanted for polygraphic recordings. Four different states of vigilance were observed:. Active wakefulness, quiet wakefulness, quiet sleep and active sleep. EEG was polymorphic and irregular showing a decreasing tendency in frequency and amplitude when(More)
In a study of 66 patients with systemic lupus erythematosus (SLE) and 80 controls it was found that the presence of two deficiency (null) alleles of C4 had a significant effect on mean C4 concentrations in serum. In six controls who each had two C4 null alleles the mean C4 concentration in serum was 56% lower than in 43 controls without C4 null alleles; the(More)
Recently reported sham feeding studies have revealed that the rate of ingestion of liquid diets early in the ingestion interval is under the associative control of postingestive events occurring in the stomach and intestine. This study investigated the possibility that gastrointestinal filling induced by adding the nonabsorbable sugar alcohol mannitol to a(More)
BACKGROUND The pharmacokinetics and pharmacodynamics of a novel orally disintegrating tablet (ODT) formulation of delayed-release dexlansoprazole 30 mg was evaluated versus the dexlansoprazole 30 mg capsule in this phase I, open-label, multiple-dose, randomized, two-period crossover study. METHODS Healthy adults received daily doses of 30 mg(More)
OBJECTIVE To evaluate the safety and pharmacokinetic profile of dexlansoprazole modified-release (MR) capsules in pediatric patients with symptomatic gastroesophageal reflux disease (GERD). METHODS This Phase I, open-label study enrolled male and female patients (1 to 11 years of age) with GERD. Patients received dexlansoprazole MR 15 mg, 30 mg, or 60 mg(More)
It has been reported that the addition of Acarbose, a alpha-glucosidase inhibitor, to a carbohydrate solution blocks a preference that otherwise would be displayed for that solution. One interpretation of those results is that the alteration in preference was caused by the diminished postabsorptive nutritive value of the diet due to the inhibition of(More)
BACKGROUND Dual delayed-release dexlansoprazole is approved for use in adults as a 30 mg orally disintegrating tablet (ODT) or as 30 mg and 60 mg capsules. The pharmacokinetics, pharmacodynamics, and safety profile of two dexlansoprazole 30 mg ODTs were compared with one dexlansoprazole 60 mg capsule in this randomized, phase I, open-label, single-center,(More)