Maria C Heidkamp

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Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in adhesion-dependent signal transduction. FAK is highly expressed in cultured neonatal rat ventricular myocytes (NRVMs) and undergoes tyrosine autophosphorylation in response to cell adhesion, stretch, and growth factor stimulation. We previously showed that inhibition of FAK(More)
Patients with cardiac hypertrophy and heart failure display abnormally slowed myocardial relaxation, which is associated with downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) gene expression. We previously showed that SERCA2 downregulation can be simulated in cultured neonatal rat ventricular myocytes (NRVM) by treatment with the protein(More)
The nonreceptor protein tyrosine kinase (PTK) proline-rich tyrosine kinase 2 (PYK2) has been implicated in cell signaling pathways involved in left ventricular hypertrophy and heart failure, but its exact role has not been elucidated. In this study, replication-defective adenoviruses (Adv) encoding green fluorescent protein (GFP)-tagged, wild-type (WT), and(More)
December 2010 marked the three-year anniversary of the start of the Great Recession. Though technically over in June 2009, the Great Recession has left 15 million people unemployed, 2.1 million of them over age 55. In addition, the Bureau of Labor Statistics (BLS) reported that there were 1.3 million " discouraged workers " in December 2010 — individuals(More)
In the wake of the Great Recession, many older Americans hope that education and training programs will help them remain in their jobs or return to work. Unfortunately, many older workers are not well informed about the skills they need or the best and most cost-effective way to obtain them. Adults seeking education and training encounter a vast array of(More)
This report is part of the Future of Work@50+ Initiative. This is a multiyear initiative that examines the challenges and opportunities facing older workers. For other reports and information, visit: AARP's Public Policy Institute informs and stimulates public debate on the issues we face as we age. Through research, analysis, and dialogue with the nation's(More)
As Americans remain in the workforce longer due to increased life expectancy, personal preference, and economic need, many adults seek education and training to gain the skills and credentials needed to start new careers or advance in their current careers. Community colleges, with their open access and focus on workforce preparation, are often highlighted(More)
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