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  • Maria C Edman, Tanja Jarhede, Michael Sjöström, Åke Wieslander
  • Chemistry, Medicine
  • Proteins
  • 1999 (First Publication: 1 May 1999)
  • Signal peptides are essential N-terminal extensions in export proteins, and have a positively charged N-terminus, a hydrophobic central core, and a C-terminal cleavage region. They interact in aContinue Reading
  • Mihir Shah, Maria C Edman, +7 authors Sarah F Hamm-Alvarez
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 2013 (First Publication: 1 November 2013)
  • Sjögren's syndrome (SjS) is a chronic autoimmune disease characterized initially by lymphocytic infiltration and destruction of exocrine glands, followed by systemic organ damage and B-cell lymphoma.Continue Reading
  • Maria C Edman, Srikanth R Janga, +16 authors Sarah F Hamm-Alvarez
  • Medicine
  • Scientific Reports
  • 2018 (First Publication: 23 July 2018)
  • Cathepsin S (CTSS) activity is elevated in Sjögren’s Syndrome (SS) patient tears. Here we tested whether protease inhibition and cystatin C (Cys C) levels are reduced in SS tears, which could lead toContinue Reading
  • Zhen Meng, Wannita Klinngam, Maria C Edman, Sarah F Hamm-Alvarez
  • Biology, Medicine
  • PloS one
  • 2017 (First Publication: 13 September 2017)
  • Inflammation and impaired secretion by lacrimal and salivary glands are hallmarks of the autoimmune disease, Sjögren’s Syndrome. These changes in the lacrimal gland promote dryness and inflammationContinue Reading
  • Zhen Meng, Maria C Edman, +5 authors Sarah F Hamm-Alvarez
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 2016 (First Publication: 1 June 2016)
  • The mechanism responsible for the altered spectrum of tear proteins secreted by lacrimal gland acinar cells (LGAC) in patients with Sjögren's Syndrome (SS) remains unknown. We have previouslyContinue Reading