Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Binding of tricyclic antidepressants and perazine to human plasma

• Maria Brinkschulte, Ursula Breyer-Pfaff
• Naunyn-Schmiedeberg's Archives of Pharmacology
• 1979

The binding of amitriptyline (AT), nortriptyline (NT), imipramine (IP), desmethylimipramine (DMI) and perazine (PER) to plasma from healthy volunteers was measured by equilibrium dialysis at 37°C.… (More)

Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels

• Ursula Breyer-Pfaff, Hans Jörg Gaertner, Franz Kreuter, Günther Scharek, Maria Brinkschulte, R. Wiatr
• Psychopharmacology
• 1982

In 27 inpatients with primary affective disorder the urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was measured prior to a 4-week treatment with 150 mg amitriptyline (AT)/day. Ratings… (More)

Prediction and evaluation criteria in perazine therapy of acute schizophrenics. Pharmacokinetic data.

• Ursula Breyer-Pfaff, Maria Brinkschulte, Werner Rein, H. W. Schied, Eckart R. Straube
• Pharmacopsychiatria
• 1983

Twenty-eight patients with acute schizophrenic illness received an oral daily dose of 200-800 mg perazine (Taxilan) for 4 weeks. Weekly plasma level determinations showed a constant perazine… (More)

The contribution of α 1-acid glycoprotein, lipoproteins, and albumin to the plasma binding of perazine, amitriptyline, and nortriptyline in healthy man

• Maria Brinkschulte, Ursula Breyer-Pfaff
• Naunyn-Schmiedeberg's Archives of Pharmacology
• 1980

Parameters for the binding of perazine (PER), amitriptyline (AT) and nortriptyline (NT) to plasma and to single plasma proteins were determined by equilibrium dialysis. The highest affinity (K at… (More)

Plasma protein binding of perazine and amitriptyline in psychiatric patients

• Maria Brinkschulte, Hans Jörg Gaertner, H. W. Schied, Ursula Breyer-Pfaff
• European Journal of Clinical Pharmacology
• 1982

The free fraction of amitriptyline (AT), measured by equilibrium dialysis in plasma from 29 AT-treated depressed patients, was 5.4–9.8% (mean 7.7%), which was the same as the values in 26 healthy… (More)

Increased binding of desmethylimipramine in plasma of phenobarbital-treated rats.

• Maria Brinkschulte, Ursula Breyer-Pfaff
• Biochemical pharmacology
• 1982

In plasma of untreated male Wistar rats the mean free fraction of desmethylimipramine (DMI) amounted to 10.5%. A five-day oral treatment with phenobarbital (PB) reduced it to 6.2%. A similar effect… (More)

Binding of tricyclic psychoactive drugs in plasma: contribution of individual proteins and drug interactions.

• Ursula Breyer-Pfaff, Maria Brinkschulte
• Progress in clinical and biological research
• 1989

• ‹
• 1
• ›