Maria Antonietta Secci

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Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion. The Italian island of Sardinia exhibits a very high frequency(More)
Multiple sclerosis (MS) is consistently associated with particular HLA-DRB1-DQB1 haplotypes. However, existing evidence suggests that variation at these loci does not entirely explain association of the HLA region with the disease. The MOG locus is a prime positional and functional candidate for such additional predisposing effects but the analysis is(More)
The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS). Furthermore, the two diseases tend to be co-inherited in the same individuals and in the same families. These observations suggest that some unknown autoimmunity variant with relevant effect size could be fairly(More)
BACKGROUND The strongest genetic determinant for multiple sclerosis (MS) is located at the human leukocyte antigen (HLA) class II DRB1 and DQB1 loci. OBJECTIVES To investigate the possible role of predisposing HLA genotypes in determining brain atrophy. METHODS HLA genotypes were categorized as high risk (two predisposing haplotypes) or medium/low risk(More)
Authors: Maristella Pitzalis (marist@mcweb.unica.it) Patrizia Zavattari (zavatta@mcweb.unica.it) Raffaele Murru (rmurru@unica.it) Elisabetta Deidda (edeidda@mcweb.unica.it) Magdalena Zoledziewska (magdaz@mcweb.unica.it) Daniela Murru (danielmurru@tiscali.it) Loredana Moi (lmoi@mcweb.unica.it) Costantino Motzo (costantino.motzo@tiscali.it) Valeria Orru(More)
Authors: Maristella Pitzalis (marist@mcweb.unica.it) Patrizia Zavattari (zavatta@mcweb.unica.it) Raffaele Murru (rmurru@unica.it) Elisabetta Deidda (eli.deidda@mcweb.unica.it) Magdalena Zoledziewska (magdaz@mcweb.unica.it) Daniela Murru (danielmurru@tiscali.it) Loredana Moi (lmoi@mcweb.unica.it) Costantino Motzo (costantino.motzo@tiscali.it) Valeria Orru(More)
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