Maria Anna Köllner

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The sensitivity limit for one-lane DNA sequencing based on laser-induced fluorescence is derived by statistical means. A closed-form expression for the sequencing error probability as a function of the signal strength and of the differences in the fluorescence properties of the labels is given. Fluctuations of the signal caused by photodestruction of the(More)
This research was carried out to study the pharmacological activity of a newly synthesized series of 2-alkoxy-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as adenosine receptor antagonists. These compounds have been tested in radioligand binding assays on cloned Chinese hamster ovary (CHO) cells transfected with A(1), A(2A), A(2B) and A(3) receptors. In(More)
DNA libraries often contain very large numbers of clones (from 1000 up to 700,000). Since at present it is impossible to analyze all of these clones, usually statistical samples comprising less than 100 clones are tested. The quality of the library is then assessed by linear extrapolation. Occasionally, full coverage of chromosomal regions by DNA probes is(More)
The anthranilic scaffold plays an important role as a pharmacophore and toxophore in medicinal and agricultural chemistry and contributes to a variety of biological activities [1 – 9]. Although ring-closure reactions of N-unsubstituted anthranilic acid derivates have been extensively elaborated, investigations towards the corresponding chemistry of(More)
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