Maria Alice Rostom de Mello

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The Human Immunodeficiency Virus Type 1 (HIV-1) presents a high level of genetic variation leading to isolates with divergent nucleotide and amino acid sequences and distinct biological properties. This viral diversity is one of the main obstacles for the development of a universal effective vaccine. Based on HIV-1 env and gag gene sequence data, at least(More)
To evaluate the effect of acute exercise and exercise training at the anaerobic threshold (AT) intensity on aerobic conditioning and insulin secretion by pancreatic islets, adult male Wistar rats were submitted to the lactate minimum test (LMT) for AT determination. Half of the animals were submitted to swimming exercise training (trained), 1 h/day, 5(More)
Hox genes are well-known regulators of pattern formation and cell differentiation in the developing vertebrate skeleton. Although skeletal variations are not uncommon in humans few mutations in human HOX genes have been described. If such mutations are compatible with life, there may be physiological modifiers for the manifestation of Hox gene-controlled(More)
This study was undertaken to characterize the effects of the linear periodized training in rats on aerobic and anaerobic performance, glycogen concentration in soleus, gastrocnemius and liver, hormones concentrations (testosterone and corticosterone), enzymes and metabolites (creatine kinase, lactate dehydrogenase, creatinine, uric acid and urea) as well as(More)
BACKGROUND Hox genes encode transcription factors that are involved in pattern formation in the skeleton, and recent evidence suggests that they also play a role in the regulation of endochondral ossification. To analyze the role of Hoxc-8 in this process in more detail, we applied in vitro culture systems, using high density cultures of primary(More)
The human immunodeficiency virus type 1 (HIV-1), the etiological agent of the acquired immunodeficiency syndrome (AIDS), shows a variety of biological properties, which may constitute an obstacle to development of effective vaccines or antiretroviral therapy. To characterize Brazilian strains of HIV-1, we studied 24 viruses isolated from blood samples of(More)
Laboratory rats, when kept in conditions regarded as "standard", are physically inactive, do not have proper environmental stimulation and have free access to food, which can lead to metabolic syndrome and fat accumulation in the liver. This study aimed to analyse the susceptibility of "control animals", which have free access to food, to metabolic syndrome(More)
OBJECTIVE The objective of this study was to analyze the effect of Spirulina and/or exercise training in the control of serum glucose homeostasis in diabetic rats. MATERIALS AND METHODS Young Wistar rats were induced to diabetes by intravenous alloxan administration and separated into four groups: diabetic control (DC), diabetic Spirulina (DS), diabetic(More)
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