Learn More
Genetic strategies to improve the profitability of sheep operations have generally focused on traits for reproduction. However, natural mutations exist in sheep that affect muscle growth and development, and the exploitation of these mutations in breeding strategies has the potential to significantly improve lamb-meat quality. The best-documented mutation(More)
To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We(More)
The identification of genes controlling several traits of interest in sheep has been accomplished by positional candidate cloning. In these studies, the trait is first mapped to a specific chromosomal region by linkage analysis, which requires families that are segregating for the trait and for polymorphic markers. Microsatellite markers are usually used(More)
The callipyge mutation (CLPG) is an A to G transition that affects a muscle-specific long-range control element located in the middle of the 90-kb DLK1-GTL2 intergenic (IG) region. It causes ectopic expression of a 327-kb cluster of imprinted genes in skeletal muscle, resulting in the callipyge muscular hypertrophy and its non-Mendelian inheritance pattern(More)
Ovine hereditary chondrodysplasia, or spider lamb syndrome (SLS), is a genetic disorder that is characterized by severe skeletal abnormalities and has resulted in substantial economic losses for sheep producers. Here we demonstrate that a non-synonymous T>A transversion in the highly conserved tyrosine kinase II domain of a positional candidate gene,(More)
  • Benedetti M, C Boatella, +32 authors Zweifel P
  • 2005
We report on the development of the LISA Technology Package (LTP) experiment that will fly on board the LISA Pathfinder mission of the European Space Agency in 2008. We first summarize the science rationale of the experiment aimed at showing the operational feasibility of the so called Transverse-Traceless coordinate frame within the accuracy needed for(More)
In this article we describe the organization of the ovine BEGAIN gene, located 138 kb proximally from the imprinted DLK1 gene and 203 kb from the CLPG mutation that causes the callipyge phenotype. We have shown that in sheep BEGAIN is ubiquitously expressed, including in skeletal muscle, throughout development. We have identified four major BEGAIN(More)
Front cover artwork: The cover art depicts the structure of the eukaryotic ribosome from the yeast Saccharomyces cerevisiae. The ribosome consists of four RNA chains (gray ribbons) and 79 different proteins (colored ribbons). With a total mass of 3.3 MDa, it is more intricate and $40% larger than its bacterial counterpart. The previous edition of the(More)
callipyge phenotype (Gk calli-beautiful +-pyge buttocks) is a generalized muscular hypertrophy described in sheep. It is due to an increase in the size and proportion of fast twitch muscle fibers. It manifests itself only after birth at ~1 month of age. It exhibits a rostro-caudal gradient being more pronounced in the muscle of the pelvic limb and torso,(More)