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Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons.

• Pamela I Osterlund, Jaana Pirhonen, +8 authors Ilkka Julkunen
• Journal of virology
• 2010

In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct… (More)

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

• Mari Strengell, Sampsa Matikainen, +4 authors Timo Sareneva
• Journal of immunology
• 2003

NK and T cell-derived IFN-gamma is a key cytokine that stimulates innate immune responses and directs adaptive T cell response toward Th1 type. IL-15, IL-18, and IL-21 have significant roles as… (More)

High frequency of cross-reacting antibodies against 2009 pandemic influenza A(H1N1) virus among the elderly in Finland.

• Niina H Ikonen, Mari Strengell, +6 authors Ilse Julkunen
• Euro surveillance : bulletin Europeen sur les…
• 2010

Since May 2009, the pandemic influenza A(H1N1) virus has been spreading throughout the world. Epidemiological data indicate that the elderly are underrepresented among the ill individuals.… (More)

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

• Sanna M. Mäkelä, Mari Strengell, Taija E. Pietilä, Pamela I Osterlund, Ilkka Julkunen
• Journal of leukocyte biology
• 2009

TLRs are innate immune receptors that recognize pathogen-associated structures. Binding of ligands to different TLRs can induce the production of proinflammatory cytokines in a synergistic manner. We… (More)

IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response.

• Mari Strengell, Timo Sareneva, Don Foster, Ilkka Julkunen, Sampsa Matikainen
• Journal of immunology
• 2002

IL-21 is a recently characterized T cell-derived cytokine that regulates NK and T cell function. IL-21R shares the common gamma-chain (gamma(c)) with the receptors for IL-2, IL-4, IL-7, IL-9, and… (More)

Minor Changes in the Hemagglutinin of Influenza A(H1N1)2009 Virus Alter Its Antigenic Properties

• Mari Strengell, Niina H Ikonen, T. Ziegler, Ilkka Julkunen
• PloS one
• 2011

BACKGROUND The influenza A(H1N1)2009 virus has been the dominant type of influenza A virus in Finland during the 2009-2010 and 2010-2011 epidemic seasons. We analyzed the antigenic characteristics of… (More)

Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry.

• Pamela I. Österlund, Mari Strengell, +4 authors Ilkka Julkunen
• Journal of virology
• 2012

The activation of the interferon (IFN) system, which is triggered largely by the recognition of viral nucleic acids, is one of the most important host defense reactions against viral infections.… (More)

DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector.

• Marko Tähtinen, Mari Strengell, +9 authors Karsten Krohn
• Vaccine
• 2001

The immunogenicity of a self-replicating DNA-vector containing HIV-1 nef gene (pBN-Nef) was characterized using various DNA delivery methods. In addition, gene gun immunisation was used for assessing… (More)

Critical immunological pathways are downregulated in APECED patient dendritic cells

• Nora Pöntynen, Mari Strengell, +4 authors Leena Peltonen
• Journal of Molecular Medicine
• 2008

Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) is a monogenic autoimmune disease caused by mutations in the autoimmune regulator (AIRE) gene. AIRE functions as a… (More)

IL-21 in Synergy with IL-15 or IL-18 Enhances IFN- Production in Human NK and T Cells

• Timo Sareneva, Mari Strengell, +4 authors Ilkka Julkunen
• 2003

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