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It has been reported that relatively short RNAs of heterogeneous sizes are derived from sequences near the promoters of eukaryotic genes. In conjunction with the FANTOM4 project, we have identified tiny RNAs with a modal length of 18 nt that map within -60 to +120 nt of transcription start sites (TSSs) in human, chicken and Drosophila. These transcription(More)
The rice species Oryza sativa is considered to be a model plant because of its small genome size, extensive genetic map, relative ease of transformation and synteny with other cereal crops. Here we report the essentially complete sequence of chromosome 1, the longest chromosome in the rice genome. We summarize characteristics of the chromosome structure and(More)
BACKGROUND Small RNA attracts increasing interest based on the discovery of RNA silencing and the rapid progress of our understanding of these phenomena. Although recent studies suggest the possible existence of yet undiscovered types of small RNAs in higher organisms, many studies to profile small RNA have focused on miRNA and/or siRNA rather than on the(More)
It is becoming increasingly clear that alternative splicing enables the complex development and homeostasis of higher organisms. To gain a better understanding of how splicing contributes to regulatory pathways, we have developed an alternative splicing library approach for the identification of alternatively spliced exons and their flanking regions by(More)
Rice (Oryza sativa L.) is a model organism for the functional genomics of monocotyledonous plants since the genome size is considerably smaller than those of other monocotyledonous plants. Although highly accurate genome sequences of indica and japonica rice are available, additional resources such as full-length complementary DNA (FL-cDNA) sequences are(More)
We propose a method of automatically generating qualitative equations, i.e., monotonic and dierential relations among the variables, to model and analyze macro-behaviors of foraging in ant colony. Foraging is a well-coordinated group behavior of ant colony, which is achieved by the cooperation of individual ants. We executed numerical simulations for the(More)
In this paper, we present a method to qualitatively compute the global characteristics of causal graphs by the analysis of the underlying dynamical systems, rather than traditional qualitative simulations which suer from intractability and diculty in understanding their simulation results. The key idea is to translate a given causal graph into an autonomous(More)
OBJECTIVE We determined adoption rates of pediatric-oriented electronic health record (EHR) features by US children's hospitals and assessed perceptions regarding the suitability of commercial EHRs for pediatric care and the influence of the meaningful use incentive program on implementation of pediatric-oriented features. MATERIALS AND METHODS We(More)
In order to deal with unexpected or illegal behavior of multi-agent systems, we have to reorganize the system's behavior by redening or re-planning each agent's behavior. In that case, the underlying mathematical model connecting the target system's behavior and each agent's behavior is indispensable. In this paper, we present a method for generating causal(More)