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Cognitive training has been a growing field in recent years. It is established that training improves cognitive abilities in healthy elderly people. Specialized software and commercial devices including the possibility of cognitive gaming has been placed into the market; most of them are based on neuropsychological models of cognitive aging, but few have(More)
OBJECTIVE To analyze the associations of HLA class II antigens with rheumatoid arthritis (RA) in a Spanish population. METHODS We used DNA oligotyping to determine DR types, DQA1 and DQB1 alleles, and DR4 variants in 70 unrelated seropositive RA patients and 189 healthy controls living in Spain. RESULTS A significantly higher frequency of DR4 was seen(More)
In order to examine the effect of an avatar in natural interaction with elderly users in ambient intelligent environments, we performed an empirical study with elderly people (normal aging, mild cognitive impairment and Alzheimer's patients) not only on subjective but also on objective measures. The data supports the following: 1) The subjects followed some(More)
Nasopharyngeal carcinoma has a well-defined geographic distribution, primarily affecting persons from southern China and Southeast Asia. Environmental factors are numerous and appear to have a secondary role, mainly in the promotion of the neoplastic process. Relationship with the Epstein-Barr virus is indicated by the identification of viral genome copies(More)
The complexity of new information technologies (IT) may limit the access of elderly people to the information society, exacerbating what is known as “the digital divide,” as they appear to be too challenging for elderly citizens regardless of the integrity of their cognitive status. This study is an attempt to clarify how some cognitive functions (such as(More)
INTRODUCTION The cognitive assessment of patients with advanced dementia needs proper screening instruments that allow obtain information about the cognitive state and resources that these individuals still have. The present work conducts a Spanish validation study of the Severe Mini Mental State Examination (SMMSE). MATERIAL AND METHODS Forty-seven(More)
Peripheral blood lymphocytes from two polytransfused renal dialysis patients were transformed by Epstein-Barr virus, fused to a heteromyeloma and cloned. Eight human monoclonal antibodies from the resulting clones were tested for their binding to a variety of antigens by ELISA, indirect immunofluorescence and immunoblotting. Antigens tested included B-cell(More)