Mari-Anne Härma

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Brain-derived neurotrophic factor (BDNF) is a secreted protein of the neurotrophin family that regulates brain development, synaptogenesis, memory and learning, as well as development of peripheral organs, such as angiogenesis in the heart and postnatal growth and repair of skeletal muscle. However, while precise regulation of BDNF levels is an important(More)
Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival of dopamine neurons in vitro and in vivo, intracranial delivery of GDNF has been attempted for Parkinson's disease treatment but with variable success. For improving GDNF-based(More)
Gdnf, its binding receptor Gfrα1 or its main signaling receptor Ret die after birth mainly as a result of the lack of kidneys, but with intact catecholamine system, rendering postnatal analysis impossible4. However, conditional ablation using a loxP-Cre system (referred to as floxed) of GDNF main signaling receptor Ret and Gdnf have yielded conflicting(More)
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