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Neuron/glial 2 (NG2)-expressing cells are often referred to as oligodendrocyte precursor cells. NG2-expressing cells have also been identified as multipotent progenitor cells. However, microglia-like NG2 glial cells have not been fully examined in neurodegenerative disorders such as Parkinson's disease (PD). In the present study, we chose two rat models of(More)
Business analysis with processes extracted from real-life system logs has recently become important for improving business performance. Since business users desire to see the current situations of business with visualized process models from various perspective, we need an analysis platform that supports changes of viewpoint. We have developed a runtime(More)
Chronic systemic exposure of Lewis rats to rotenone produced many features of Parkinson's disease (PD), including nigrostriatal dopamine (DA) neurodegeneration and the formation of cytoplasmic inclusions in nigral DA neurons. We also reported that chronic oral administration of rotenone at 30 mg/kg for 28 d caused specific nigrostriatal DA neurodegeneration(More)
L-Dihydroxyphenylalanine (L-DOPA) is considered the gold standard for the treatment of Parkinson's disease (PD). However, long-term administration of L-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitors (SSRIs) including fluoxetine have gained tremendous popularity in the treatment of depression in PD. SSRIs(More)
This paper describes our approach to support the development of large-scale Web applications. Large development efforts have to be divided into a number of smaller tasks of different kinds that can be performed by multiple developers. Once this process has taken place, it is important to manage the consistency among the artifacts in an efficient and(More)
Web annotation is crucial for providing machine-understandable descriptions of Web resources, and has a number of applications such as discovery, qualification, and adaptation of Web documents. While annotations are often embedded into a Web document, annotations can be associated externally by means of addressing expressions represented with the XPath(More)
To monitor and warrant the performance of concerned business operations, formal representation for business performance models are needed so business analysts can describe what they expect from business service providers. This paper proposes a metamodel and an authoring tool for describing business performance for business services in the context of SOA. A(More)