Marguerite E. Barratt

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Explants of articular cartilage from young pigs were maintained in organ culture for 10--16 days, and degradation of matrix was induced by retinol or complement-sufficient antiserum. The percentage breakdown of proteoglycan and collagen (as hydroxyproline release) was measured. The response of the cartilage depended on whether or not the explants were cut(More)
Serum antibody responses to ingested aqueous alcohol-extracted soya proteins were studied in thirty-six pre-ruminant calves. Characterization of this antibody showed it to be predominantly a complement-fixing IgG1 preciptin. No evidence of tolerance was seen; previously sensitized calves responded to reintroduction of a soya diet with marked increases in(More)
Background: Breastfeeding and weaning are strongly connected with infant– mother mutual autonomy, and hence are good touchstones to examine the characteristics of the mother–child relationship. Comparison of the weaning practice gives a framework to understand characteristics of the mother–infant relationship. Objective: The purpose of this study was to(More)
Explants of pig articular cartilage including invading marrow and subchondral bone (together=‘invasion zone’) were cultivated for 10 or 14 days in complement-sufficient rabbit antiserum to pig erythrocytes (AS+C′), and then transferred to heat-inactivated normal rabbit serum (NRS) for a period of recovery. In AS+C′ the cartilage matrix lost first(More)
Previous work showed that in organ culture pig articular cartilage is not affected by complement-sufficient antiserum to pig erythrocytes (AS plus C') unless it is associated with soft connective tissue. In the presence of synovial tissue the matrix becomes depleted of proteoglycan and may finally disintegrate. Immunoglobulin fails to enter normal cartilage(More)
I. The effect of trypsinization. Certain physiological and immunological properties of isolated intimal synoviocytes were studied in various in vitro systems. Suspensions of the synoviocytes were obtained by incubating sheets of joint capsule in a solution of trypsin and then scraping off the intimal cells with a small knife. Synovium was examined(More)