Margreth Hell

Learn More
AIMS To determine the frequency of HER2 genetic heterogeneity according to the recent American Society of Clinical Oncology (ASCO) and College of American Pathologists (CAP) definition (2009) in invasive breast carcinoma, and to identify clinicopathological features that characterise breast carcinomas with HER2 genetic heterogeneity. METHODS 530 invasive(More)
BACKGROUND Positive HER2 status identifies breast carcinomas that might respond to trastuzumab treatment. Manual HER2 fluorescent in situ hybridisation (FISH) is the most readily used method to detect HER2 gene amplification which defines positive HER2 status in addition to HER2 protein overexpression. Automation of HER2 FISH may improve HER2 gene testing.(More)
BACKGROUND AND STUDY AIMS The current gold standard in Barrett's esophagus monitoring consists of four-quadrant biopsies every 1-2 cm in accordance with the Seattle protocol. Adding brush cytology processed by digital image cytometry (DICM) may further increase the detection of patients with Barrett's esophagus who are at risk of neoplasia. The aim of the(More)
All of 5 patients with rheumatoid disease presented with the rare complication of rheumatoid pleurisy or pericarditis. The lesion was diagnosed cytologically from effusions by means of the characteristic cellular findings. The unique cytologic picture and possible differential diagnoses are presented in detail. The pathogenesis of rheumatoid serositis and(More)
Die Computertomographie (CT) spielt eine wesentliche und zunehmend wichtige Rolle in der präinterventionellen Diagnostik bei Patienten, die für eine kathetergestützte Aortenklappenimplantation (TAVI) vorgesehen sind. Die CT-Bildgebung (sie muss zwingend mit Kontrastmittel durchgeführt werden) ermöglicht eine umfassende Beurteilung sowohl des Zugangsweges(More)
An important prerequisite for densitometric and morphometric measurements on cytological specimens is the standardized cell preparation. Optimal results can only be achieved when the analyses are carried out on a regular monolayer of cell nuclei. Comparing the conventional cytological smear with a new centrifugation technique we demonstrate statistically(More)
  • 1