Margit Anna Huber

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The invention of targeted therapy for advanced stage melanoma has made it necessary to perform a mutation analysis of each melanoma case in order to detect the BRAF V600E mutation required for the prescription of selective BRAF inhibitors. In this new clinical context it is important to realize that the tumour seeds may come from different tumour clones and(More)
Discovery and translational research has led to the identification of a series of " cancer drivers " —genes that, when mutated or otherwise misregulated, can drive malignancy. An increasing number of drugs that directly target such drivers have demonstrated activity in clinical trials and are shaping a new landscape for molecularly targeted cancer(More)
The invention of targeted therapy for BRAF mutated advanced stage melanoma has given the patients the perspective of a possible longer remission of the disease based on taking several pills a day without a further hospital stay. That is the ideal situation. However, the new drugs are not without side effects. Amongst them, fever and acute arthralgia are(More)
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