Margherita Veroni

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OBJECTIVE To describe the results of a program for detecting high cardiovascular risk in an urban Aboriginal community. DESIGN Cardiovascular risk assessment program conducted between January 1998 and October 1999. Participants completed a questionnaire and underwent a physical assessment and biochemical tests. PARTICIPANTS 738 self-selected members of(More)
Both primary and acquired resistance to the growth-inhibitory effects of anti-estrogens (e.g., tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. The new, steroidal anti-estrogen ICI 182,780 was tested for its ability to inhibit the proliferation of a tamoxifen-resistant variant of the parental MCF-7 human(More)
The ratios of age-standardized mortality rates of Aboriginals to non-Aboriginals in Western Australia during the period 1983-1989 were 2.6 for males and 3.0 for females. Mortality rates experienced by Aboriginals were much higher in all age categories except 75+ years and for most major diseases except neoplasms. The peaks of all-cause age-specific(More)
BACKGROUND Aboriginals have higher hospitalisation and mortality rates and die, on average, about 15 years earlier than non-Aboriginals in Western Australia (WA). AIMS To investigate Aboriginal morbidity and mortality rates in WA in comparison with the rest of the population, with particular reference to the ages of 50 to 65 years. METHODS Mortality(More)
Several neuroendocrine abnormalities reported in the spontaneously hypertensive rat (SHR) suggest that the function of the dopaminergic tuberoinfundibular tract is impaired in this strain. SHR were pretreated with the peripheral acting inhibitor of dopa decarboxylase, carbidopa, or vehicle. Intravenous injection of L-dopa, the precursor of dopamine, lowered(More)
Vasodepressor responses to prostacyclin, nitroprusside and arachidonic acid were compared in two groups of anaesthetized, two-kidney, one-clip Goldblatt rats. The groups were composed of rats which had high blood pressure (greater than 150 mmHg systolic) or normal blood pressure (less than 140 mmHg systolic). The vasodepressor effects of prostacyclin and(More)
The transient vasodepressor action of Met-enkephalin (10-80 micrograms kg-1, i.v.) in anaesthetized rats was significantly potentiated by the angiotensin-converting enzyme inhibitor, captopril (2 mg kg-1, i.v.); at this dose, it failed to modify the transient vasodepressor action of the non-specific vasodilator, nitroprusside (2.5, 5.0, 10 micrograms kg-1,(More)
1. Tritiated digoxin was injected intravenously into euthyroid, hyperthyroid and hypothyroid rats. The rats were killed at intervals up to 24 h and tritium in serum and tissues counted. 2. Serum concentrations of tritium in the hyperthyroid animals were less than in the control group, whereas the concentrations in the hypothyroid group were similar to those(More)