Margarida Dantas Brito

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Celiac disease is an autoimmune disorder in which a genetic predisposition and the ingestion of wheat gluten triggers a deleterious immune response. This response is complex and may lead to manifestations other than enteropathyha: hepatitis, dermatitis and neuropathy. There is higher risk for neoplasia. We observed an atypical case, corresponding to a(More)
BACKGROUND A contemporary US study showed an increase in the use of chemotherapy in the last decade for some patients with stage-I breast cancer; with a rise in more intensive regimens, and declining use of anthracyclines. Nevertheless, there is still uncertainty on the absolute benefit of chemotherapy for these patients and the optimal regimen. In this(More)
1. We assessed five quantitative methods for the determination of urinary total proteins, three of them with precipitation followed by spectrophotomollowed by spectrophotometry (Tsuchyga/Benedict, Tsuchyga/Biuret and TCA/Biuret); one with gel-filtration (Sephadex G50/Biuret) and a Turbidimetric procedure (SSA). 2. Day-to-day precision was between 3.58 %CV(More)
BACKGROUND Since 2005, aromatase inhibitors (AIs) have been the adjuvant treatment of choice for postmenopausal women with early breast cancer (BC). In this study we characterize the adoption of AIs in Portugal, variables associated with treatment administration, and compare its effectiveness (either in monotherapy or sequential therapy) to tamoxifen(More)
BACKGROUND The antiangiogenic drug sunitinib has never been evaluated as single agent in untreated breast cancer patients. OBJECTIVE We aimed to characterize the activity of sunitinib, alone and with docetaxel, in untreated locally advanced or operable breast cancer and to uncover the mechanisms of response. METHOD Patients were treated with an upfront(More)
Observing how long a dynamical system takes to return to some state is one of the most simple ways to model and quantify its dynamics from data series. This work proposes two formulas to estimate the KS entropy and a lower bound of it, a sort of Shannon’s entropy per unit of time, from the recurrence times of chaotic systems. One formula provides the KS(More)
De Haan and Pereira [1] provided models for spatial extremes in the case of stationarity, which depend on just one parameter β > 0 measuring tail dependence, and they proposed different estimators for this parameter. This framework was supplemented in [2] by establishing local asymptotic normality (LAN) of a corresponding point process of exceedances above(More)
BACKGROUND Breast cancer clinical trials prove better outcomes for anthracycline-taxane regimes albeit of a higher hematologic toxicity. Original trials may under-estimate febrile neutropenia (FN) event rates. OBJECTIVE To describe the occurrence of FN events related to FEC-D for breast cancer treatment in the real-life setting. METHODS Retrospective(More)
Let Z1, Z2, ... be i.i.d. random variables with tail behaviour P (Z1 > z) = r(z)e−Rz, where r is a regularly varying function at infinity and R is a positive constant. We consider the problem of estimating the exponential tail coefficient R, by methods mainly based on least squares considerations. Using a geometrical reasoning, we introduce a consistent(More)