Margarete Tigges

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A digital high-speed camera system for the endoscopic examination of the larynx allows recording speeds of up to 5,600 frames/s. Recordings of up to 1 s duration can be stored and used for further evaluation. Combined with an image processing program the system is able to render x-t diagrams of vocal cord movement. Data acquired from different locations of(More)
Phonation onset is discussed in the framework of dynamical systems as a Hopf bifurcation, i.e., as a transition from damped to sustained vocal fold oscillations due to changes of parameters defining the underlying laryngeal configuration (e.g., adduction, subglottal pressure, muscular activity). An analytic envelope curve of the oscillation onset is deduced(More)
The calcium-binding proteins calbindin (CaBP) and parvalbumin (PV) are important in regulating intracellular calcium in brain cells. PV immunoreactivity is reduced by enucleation in the lateral geniculate nucleus (LGN) and by enucleation and visual deprivation in the striate cortex of adult monkeys. The effects of enucleation and visual deprivation on CaBP(More)
For the diagnosis of voice disorders, and especially for the classification of hoarseness, direct observation of vocal fold vibration is essential. Furthermore, a quantitative description of the movement of the vocal fold becomes increasingly necessary to document and compare findings as well as the progression of speech therapy. On the base of digital(More)
Digital multi-plane kymography is presented as a new method to demonstrate vocal fold vibration from digital high-speed recordings. Single lines from digital high-speed sequences of laryngoscopical examinations are concatenated to images, which are called kymograms. In order to reveal anterior-posterior (AP) modes of vibration several kymograms from(More)
OBJECTIVES To establish the applicability of digital high-speed imaging in studying neoglottic mucosal vibration after total laryngectomy and to perform a structured evaluation of the recordings using a standardized assessment form to gain insight about the anatomical and morphologic characteristics of the neoglottis. DESIGN Evaluation of a new clinical(More)
PURPOSE To examine the relationship of ocular components to refraction throughout the adult life span of the rhesus monkey (Macaca mulatta). METHODS Cycloplegic retinoscopy, A-scan ultrasonography, slit lamp examination, indirect ophthalmoscopy, and keratometry were performed in a cross-sectional study of 111 monkeys, aged 5 to 31 years. Lens thickness(More)
The purpose of this study was to examine the development and distribution of neuropeptide Y-immunoreactive fibers in the neurohypophysis of the rhesus monkey (Macaca mulatta) throughout life and the relationship of these fibers to the hypothalamo-hypophyseal portal vasculature. In rhesus monkeys, which varied in age from fetal life to 34 years, neuropeptide(More)
Several types of terminals were found in the three superficial collicular layers of Galago. At least two axon terminals with round vesicles (R1 and R2) could be distinguished on the basis of vesicle packing and electron density of the cytoplasmic and mitochondrial matrices. R1 axon terminals were characterized by aggregations of vesicles in an electron(More)
The case of a female patient 21 years old at the time of diagnosis is reported. The patient suffered from stage IV Hodgkin's disease of the nodular sclerotic type with head and neck manifestations in cervical lymph nodes and in the esophagus. After radiotherapy; she suffered from an esophageal/mediastinal fistula and unilateral paralysis of the recurrent(More)