Margareta Holmström

Learn More
BACKGROUND The influence of the duration of anticoagulant therapy after venous thromboembolism (VTE) on the long-term morbidity and mortality is unclear. AIM To investigate the long-term sequelae of VTE in patients randomized to different duration of secondary prophylaxis. METHODS In a multicenter trial comparing secondary prophylaxis with vitamin K(More)
BACKGROUND A consensus has not been reached about the optimal duration of oral anticoagulant therapy after a second episode of venous thromboembolism. METHODS In a multicenter trial, we compared six months of oral anticoagulant therapy with anticoagulant therapy continued indefinitely in patients who had had a second episode of venous thromboembolism. Of(More)
The variation in conformation of 356 Swedish Warmblood horses is described, using a quantitative method of measuring horses. Thirty-three of the horses were élite dressage horses, 28 were élite showjumpers, 100 were riding school horses and 195 were unselected four-year-olds. Most horses had a long body form. The average height at the withers was 163.4 cm.(More)
BACKGROUND There is uncertainty regarding the efficacy and incidence of thromboembolic events in patients treated with prothrombin complex concentrates (PCC) for the emergency reversal of warfarin effect. METHODS During 2002 to 2010 we prospectively included 160 patients treated with PCC for emergency reversal of warfarin either for bleeding or because of(More)
BACKGROUND AND PURPOSE The optimum timing of resumption of anticoagulation after warfarin-related intracranial hemorrhage in patients with indication for continued anticoagulation is uncertain. We performed a large retrospective cohort study to obtain more precise risk estimates. METHODS We reviewed charts of 2869 consecutive patients with objectively(More)
Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate- and Swedish high-dose prophylactic regimens for patients with(More)
Camptothecin (CPT) and amsacrine (m-AMSA), specific inhibitors of topoisomerase I and II, were tested for micronucleus inducing potential in bone marrow of male and female CD-1 mice. CPT was given as intraperitoneal (i.p.) injections at 0 h in doses of 1, 2 and 4 mg/kg, and at 0 + 24 h in doses of 0.5, 1 and 2 mg/kg. Bone marrow samples were taken 30 and 48(More)
INTRODUCTION von Willebrand disease (VWD) is a hereditary bleeding disorder, caused by a deficiency in the levels and/or function of von Willebrand factor (VWF). Women with VWD appear to be at increased risk of experiencing postpartum hemorrhage (PPH), though the levels of VWF increase during pregnancy. There is limited knowledge of how PPH is associated(More)
Trot in hand, working trot, collected trot, passage and piaffe of 6 Grand Prix dressage horses were recorded by high speed film (250 frames/s). Angular patterns and hoof trajectories of the left fore- and hindlimbs were analysed and presented as mean and standard deviation (s.d.) curves. Speed and stride length decreased and fore- and hind stance phase(More)
BACKGROUND Several methods exist for evaluation of hypocoagulation in patients with perioperative bleeding, e.g. thromboelastography (TEG(®)) and conventional methods (platelet count, aPTT, INR and fibrinogen). Considering the vast experience of conventional methods it is important to investigate how well the methods correspond. METHODS Sixty surgical(More)