Margaret Watts

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Evidence from a number of laboratories suggests that membrane proteins may meditate the transport of physiologic fatty acids (FA) across cell membranes. However, actual transport of unbound free fatty acids (unbound FFA) from the aqueous phase on one side of a cell membrane to the aqueous phase on the other side has not been measured previously. In this(More)
Bursting oscillations are common in neurons and endocrine cells. One type of bursting model with two slow variables has been called 'phantom bursting' since the burst period is a blend of the time constants of the slow variables. A phantom bursting model can produce bursting with a wide range of periods: fast (short period), medium, and slow (long period).(More)
Vitellogenin (Vtg) was purified from the plasma of 17β-estradiol (E2)-injected male greenback flounder,Rhombosolea tapirina. The molecular weight of the native Vtg was estimated by gel filtration as ∼ 540 kD. SDS-PAGE and Western blotting analyses indicated that this protein consisted of three bands with molecular weights of 155, 104, 79 kD, respectively. A(More)
Annie Dai, David Palensky, Alex Piatski, Kendall Queen, Gina Vockeroth, Graduate assistant: Teresa Lebair, Faculty mentor: Bradford E. Peercy, Clients: Margaret Watts and Arthur Sherman Department of Mathematics, Northeastern University Department of Mathematics, University of Maryland, College Park Department of Computer and Information Science, University(More)
Pancreatic islets exhibit bursting oscillations in response to elevated blood glucose. These oscillations are accompanied by oscillations in the free cytosolic Ca2+ concentration (Cac ), which drives pulses of insulin secretion. Both islet Ca2+ and metabolism oscillate, but there is some debate about their interrelationship. Recent experimental data show(More)
In vitro estradiol-17β (E2) and testosterone (T) production were measured in vitellogenic follicles of Atlantic salmon in response to treatment with human chorionic gonadotropin (hCG) and 2-0-dibutyryladenosine 3′,5′-cyclic monophosphate (dbcAMP). DbcAMP stimulated T production but had no effect on E2, whereas hCG treatment stimulated E2 production but T(More)
In order to further understand diabetes mellitus, it is necessary to investigate the dynamics of insulin secretion in the bloodstream. Diabetes is a disease characterized by improper concentrations of blood glucose due to irregular insulin production. Beta cells are responsible for the production and regulation of insulin based on changes in glucose levels.(More)
Pancreatic islets exhibit bursting oscillations that give rise to oscillatory Ca (2+) entry and insulin secretion from β-cells. These oscillations are driven by a slowly activating K (+) current, Kslow, which is composed of two components: an ATP-sensitive K (+) current and a Ca (2+) -activated K (+) current through SK4 channels. Using a mathematical model(More)
The regulation of glucagon secretion in the pancreatic α-cell is not well understood. It has been proposed that glucose suppresses glucagon secretion either directly through an intrinsic mechanism within the α-cell or indirectly through an extrinsic mechanism. Previously, we described a mathematical model for isolated pancreatic α-cells and used it to(More)