Margaret Watts

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Pancreatic islets exhibit bursting oscillations in response to elevated blood glucose. These oscillations are accompanied by oscillations in the free cytosolic Ca(2+) concentration (Cac ), which drives pulses of insulin secretion. Both islet Ca(2+) and metabolism oscillate, but there is some debate about their interrelationship. Recent experimental data(More)
Bursting oscillations are common in neurons and endocrine cells. One type of bursting model with two slow variables has been called 'phantom bursting' since the burst period is a blend of the time constants of the slow variables. A phantom bursting model can produce bursting with a wide range of periods: fast (short period), medium, and slow (long period).(More)
  • Annie Dai, David Palensky, Alex Piatski, Kendall Queen, Gina Vockeroth, Teresa Lebair +3 others
  • 2015
Proposal Our goal is to create a computational model of an islet of Langerhans, consisting of α-, β-, and δ-cells. We will focus on varying the geometries and proportions of the cells in this islet, and study the hormonal secretion and reception of each cell at any point in time. We are currently considering basic cubic and spherical models, among others.(More)
Pancreatic islets exhibit bursting oscillations that give rise to oscillatory Ca (2+) entry and insulin secretion from β-cells. These oscillations are driven by a slowly activating K (+) current, Kslow, which is composed of two components: an ATP-sensitive K (+) current and a Ca (2+) -activated K (+) current through SK4 channels. Using a mathematical model(More)
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