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A deeper understanding of the mechanisms that underlie plant growth and development requires quantitative data on three-dimensional (3D) morphology and gene activity at a variety of stages and scales. To address this, we have explored the use of optical projection tomography (OPT) as a method for capturing 3D data from plant specimens. We show that OPT can(More)
Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the alpha5 integrin(More)
Psychoactive substances may be given to a potential victim to alter their behaviour or conscious state. This problem is not new; alcohol has been used alone or in combination with other substances to the same effect. Doctors involved in the examination of complainants of sexual assault need to be aware of the effects of the drugs that may be used and ensure(More)
Wnt signalling is one of the fundamental cell communication systems operating in the embryo and the collection of 19 Wnt and 10 Frizzled (Fzd) receptor genes (in mouse and human) represent just part of a complex system to be unravelled. Here we present a spatially comprehensive set of data on the 3D distribution of Wnt and Fzd gene expression patterns at a(More)
Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the 5 integrin(More)
Temporary filling materials are used in endodontics to prevent contamination of the root canal system during intertreatment visits. Recently, a new composition resin (TERM) has been introduced as an interim restoration in endodontics. The purpose of this investigation was to evaluate the efficacy of this resin as an interim restoration and possible effect(More)
This paper provides a simple introduction to the reconstructions and data-handling tools stored on the Edinburgh Mouse Atlas CD, together with some of the ways in which the viewers and software can be used to understand mouse development and analyse data. The key aspect of the Mouse Atlas is that the underlying models are a complete representation of the(More)
INTRODUCTION Potentially preventable deaths in police custody include those which involve illicit drugs, alcohol and deliberate self-harm. Near miss incidents (NMI) that did not result in death have a crucial role in understanding risk factors in custody. Such research has not previously been undertaken. A program of research has been developed to study(More)
A new electric pulp-testing system, the Testark, was developed in order to assess the potential of a different way of testing pulp sensitivity, thus making this electric pulp test more dependable than the conventional electric pulp-testing method. A study was conducted to evaluate the potential of the Testark system in comparison with a commercially(More)
Large numbers of substance misusers are seen in police custody. Their management remains a significant part of a forensic physician's workload. Substance misuse, including alcohol, is a factor in a substantial number of deaths in custody. Guidelines have been produced on the acceptable minimum standards for assessment and treatment. The aims of this study(More)