Many practitioners and academicians believe that data violating fourth normal form is rarely encountered. We report upon a study of forty organizational databases; nine of them contained data violating fourth normal form. Consequently, the need to understand and user fourth normal form is more important than previously believed.
Hyperglucagonemia is implicated in the pathophysiology of hyperglycemia. Antagonism of the glucagon receptor (GCGR) thus represents a potential approach to diabetes treatment. Herein we report the characterization of GRA1, a novel small-molecule GCGR antagonist that blocks glucagon binding to the human GCGR (hGCGR) and antagonizes glucagon-induced… (More)