Margaret Reaume

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Purpose This phase III trial evaluated the efficacy and safety of pazopanib versus placebo in patients with locally advanced renal cell carcinoma (RCC) at high risk for relapse after nephrectomy.(More)
BACKGROUND The src family of kinases may play a role in the malignant phenotype through effects on migration, motility, adhesion and proliferation. The activity of saracatinib, an orally available(More)
Small cell carcinomas (SCC) most commonly arise from the lung.1 These tumours are aggressive, present with early metastasis and are associated with a poorer prognosis compared to non-small cell lung(More)
7024 Background: The eicosanoid pathway is altered in NSCLC. Pharmacological activators of peroxisome proliferator-activated receptor-gamma (PPARγ) have been shown to inhibit lung tumors in vitro.(More)