Margaret O'Brien

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OBJECTIVE To determine the relationship between paracetamol administration and skin blood flow (skBF) and blood pressure (BP) in critically ill patients treated for fever. DESIGN Prospective, observational study. SETTING Intensive care units of university teaching hospital. PATIENTS 29 adults (17 males and 12 females), aged 58±15 years treated with(More)
Epilepsy is a heterogeneous group of disorders, often associated with significant comorbidity, such as intellectual disability and skin disorder. The genetic underpinnings of many epilepsies are still being elucidated, and we expect further advances over the coming 5 years, as genetic technology improves and prices fall for whole exome and whole genome(More)
GeoLink is one of the building block projects within EarthCube, a major effort of the National Science Foundation to establish a next-generation knowledge infrastructure for geosciences. As part of this effort, GeoLink aims to improve data retrieval, reuse, and integration of seven geoscience data repositories through the use of ontologies. In this paper,(More)
Low grade oligodendrogliomas (LGO) are diffusely infiltrating World Health Organization (WHO) grade II gliomas, 20 - 30% of which show contrast enhancement. Seizures are a common presenting feature. It has been suggested that 1p19q co-deletion is associated with occurrence of seizures in adults, however, to date, the relationship of tumor genetics and(More)
The 'accuracy' of age, blood pressure, clinical features, duration and diabetes (ABCD(2)) scoring by non-stroke specialists referring patients to a daily Rapid Access Stroke Prevention (RASP) service is unclear, as is the accuracy of ABCD(2) scoring by trainee residents. In this prospective study, referrals were classified as 'confirmed TIAs' if the stroke(More)
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using(More)
Major non-cardiac surgery is associated with postoperative morbidity, and perioperative central venous oxygen saturation (ScvO2) may be a predictor of morbidity. This pilot study aimed to define intraoperative ScvO2 and to identify factors associated with postoperative complications. ScvO2 (reflection spectrophotometry) was recorded continuously in a(More)
In many scientific disciplines, including ecology, hydrology, and earth science, scientific analysis requires access to a broad range of observational data. However, because of the amount and heterogeneity both in the structure and semantics) of observational data, approaches are needed that allow scientists to easily discover and analyze them. To address(More)
GeoLink is one of the building block projects within EarthCube, a major effort of the National Science Foundation to establish a next-generation knowledge infrastructure for geosciences. Specifically, GeoLink aims to improve data reuse and integration of seven geoscience data repositories through the use of ontologies. In this paper, we present the approach(More)