Margaret O'Brien

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BACKGROUND Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not fully elucidated. Our aim was to utilise a human myometrial contractility model to investigate the effect of a number of uterine specific(More)
GeoLink is one of the building block projects within Earth-Cube, a major effort of the National Science Foundation to establish a next-generation knowledge infrastructure for geosciences. As part of this effort, GeoLink aims to improve data retrieval, reuse, and integration of seven geoscience data repositories through the use of ontologies. In this paper,(More)
BACKGROUND RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), RHOGTPase-activating proteins (RHOGAPs) and RHO guanine nucleotide inhibitors (RHOGDIs). RHOGEFs activate RHOGTPases from the inactive(More)
In many scientific disciplines, including ecology, hydrology, and earth science, scientific analysis requires access to a broad range of observational data. However, because of the amount and heterogeneity both in the structure and semantics) of observational data, approaches are needed that allow scientists to easily discover and analyze them. To address(More)
As thrombin is proposed to be involved in stimulating myometrial contractility during labor and preterm labor, we aimed to investigate the expression of prothrombin (F7), the precursor of thrombin, its receptors, the protease-activated receptor (PAR) family (F2R, F2RL1, F2RL2, and F2RL3), and prothrombinase FGL2 in human myometrium during pregnancy and(More)
BACKGROUND Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ghrelin inhibited human contractility in vitro. The aim of this study therefore, was to investigate the expression of ghrelin,(More)
GeoLink is one of the building block projects within Earth-Cube, a major effort of the National Science Foundation to establish a next-generation knowledge infrastructure for geosciences. Specifically, GeoLink aims to improve data reuse and integration of seven geoscience data repositories through the use of ontologies. In this paper, we present the(More)
We present Protégé-OWL extensions designed to help scientists define domain-specific ontologies for describing observational data. The extensions provide high-level forms that users can fill out from within Protégé to specify classes used to describe scientific measurements. As a user fills out a form, underlying OWL-DL axioms are automatically asserted,(More)
BACKGROUND Vulvar cancer is a relatively rare malignancy, which occurs most often in postmenopausal women. We have previously identified a geographic cluster of vulvar cancer in young Indigenous women living in remote communities in the Arnhem Land region of Australia. In this population, we investigated the prevalence of oncogenic human papillomavirus(More)