Margaret Laurie Comer Wright

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Resident progenitor cells in mammalian skin generate new cells as a part of tissue homeostasis. We sought to identify the progenitors of Merkel cells, a unique skin cell type that plays critical roles in mechanosensation. We found that some Atoh1-expressing cells in the hairy skin and whisker follicles are mitotically active at embryonic and postnatal ages.(More)
Atoh1 function is required for the earliest stages of inner ear hair cell development, which begins during the second week of gestation. Atoh1 expression in developing hair cells continues until early postnatal ages, but the function of this late expression is unknown. To test the role of continued Atoh1 expression in hair cell maturation we conditionally(More)
STUDY DESIGN Retrospective study comparing ScoliScore and clinical risk estimates. OBJECTIVE The purpose of this study was to compare risk stratification between ScoliScore and traditional clinical estimates to determine whether ScoliScore provides unique information. SUMMARY OF BACKGROUND DATA ScoliScore is a genetic prognostic test designed to(More)
STUDY DESIGN Consensus-based creation of a checklist and guideline. OBJECTIVE To develop a consensus-based checklist to guide surgeon responses to intraoperative neuromonitoring (IONM) changes in patients with a stable spine and to develop a consensus-based best practice guideline for IONM practice in the United States. SUMMARY OF BACKGROUND DATA(More)
Recent reviews suggest that religiosity is associated with the delay of adolescent coital debut (Rostosky, Wilcox, Wright, Randall, in press; Wilcox, Rostosky, Randall, Wright, 2001). Few studies, however, have examined this association using longitudinal data to test theoretically driven models. We analyzed data from 3,691 adolescents (ages 15-21), testing(More)
Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic Atoh1 expression drove ectopic expression of the Merkel cell marker(More)
STUDY DESIGN Multicenter, retrospective cohort study. OBJECTIVES The purpose of this study is to determine how the amount of residual lowest instrumented vertebra (LIV) tilt correlates with radiographic measurements. SUMMARY OF BACKGROUND DATA When performing a selective thoracic posterior spinal fusion for adolescent idiopathic scoliosis (AIS), the LIV(More)
BACKGROUND ScoliScore is a DNA-based prognostic test, designed and used to help to predict the risk of curve progression in patients with adolescent idiopathic scoliosis. The role of this test in clinical practice remains unclear as the published results of the ScoliScore have not been validated independently. The purpose of this study was to determine if(More)
STUDY DESIGN Retrospective cohort study. OBJECTIVES To determine the association of implant metal composition with the risk of surgical site infection (SSI) following pediatric spine surgery. SUMMARY OF BACKGROUND DATA SSI is a well-described complication following pediatric spine surgery. Many risk factors have been identified in the literature, but(More)
The objective of these experiments was to explore the possibility of preventing the rapid destruction and removal from circulation of human erythro-cytes transfused into rats. Significant prolongation of heterologous erythro-cyte survival could pave the way for development of a system that might be useful in studies of blood preservation. There also is the(More)